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1.
Strategic Management ; - (00):37-37, 2023.
Article in English | Web of Science | ID: covidwho-2307580

ABSTRACT

Background: Scientific and technical progress are unstoppable. Nowadays, information technology affects every sphere of social and economic life. The automation of business processes is a common part of business and accounting practice. Moreover, the COVID-19 pandemic has accelerated the automation in companies. Regularly occurring transactions, which were performed manually before, are gradually being replaced by information technology and automatic robotic systems. The companies fully use cloud storages, artificial intelligence, or blockchain technologies. Purpose: The purpose of the paper is to identify areas and possibilities for improvement of business and accounting processes with use of information technologies, digitalization, and automation. Methodology: For the purpose of the paper, a standard methodology review of literature sources was performed. Then we conducted a brief questionnaire survey in order to find out the level of automation and digitization of business processes in companies in the Slovak Republic. Findings and conclusions: It is expected that, as a result of robotization and automation of business processes, some professions will gradually disappear within a few decades. Even the crisis related to COVID19 pandemic had an impact on the acceleration of using information technologies in business processes related to their digitalization and automation. The paper describes possibilities of automation with focus on e-shop, which make the processes safer, faster, more effective, eco-friendly, with fewer errors. On the other hand, there are some challenges and threats the accounting entities have to consider when implementing artificial intelligence, information technology in their business processes, such as cyber security, the Internet and electricity outages. We have observed that companies in Slovakia have their business processes more or less automated. However, the automation is the domain of bigger and multinational companies. The higher initial costs related to automation are limitation for smaller companies that need to consider benefits and costs the automation requires. Limitations and future research: Our paper is based on the theoretical background with a brief research in the area of implementing information technologies in companies in the Slovak Republic. The number of returned questionnaire surveys that were the base for our brief and initial research was very low. More detailed analysis of level of automation in the Slovak companies in comparison with companies abroad, their readiness for changes related to automation, as well as threats, challenges, pros and cons of automation may be the topic for the future research.

2.
International Journal of Systems Science-Operations & Logistics ; 10(1), 2023.
Article in English | Web of Science | ID: covidwho-2310829

ABSTRACT

A global crisis such as a pandemic causes a decrease in the global trade of medical supplies. One of the most significant issues healthcare workers and people face is the shortage of personal protective equipment (PPE) items. This study constructs the first international trade model to link infectious disease dynamics and global trade networks, considering the important relationship between government preparedness, domestic manufacturers, and consumers. We examine social welfare measures here in the presence of quantity controls and taxes on the global trade flows. An equilibrium coverage among countries is investigated that integrates net government revenue, purchasing cost, transportation cost, and the health cost caused by the shortage of PPE supply. We develop an optimisation model that balances domestic firms and the global trade network to satisfy the total demand for each traded PPE product. The proportional change in value-added on domestic production is also studied by considering the marginal manufacturing costs of a face mask. The results obtained from testing our model show that the average quantity coverage by the global trade networks among four countries decreased by up to 28 % using the proposed trade policy. Hence, a large amount of demand is met by relying on domestic production.

3.
2023 International Conference on Artificial Intelligence and Smart Communication, AISC 2023 ; : 442-446, 2023.
Article in English | Scopus | ID: covidwho-2296117

ABSTRACT

The COVID-19 illness primarily carried by a Corona viral, commonly known as SARS-CoV-2. The rapid pace of such a drug's growth over six of the seven planets, except South, was already reported. Ever since it appeared, it has caused serious damage for many sectors and didn't harm the luxury goods sector. A major gate as in transition is opened by the epidemic. The COVID-19's effects on the Indian economy are negative. A old company concept needs to evolve to meet the demands of present.Through a clever absorption of internet media, method, & aptitude in any point & activity, the change as in setting of online is witnessed in all areas, i.e., in society, organisation, or in the exactness like an organisation, only in companies, or in the environment. Technology is used in conjunction with industry 4.0 (also known as DX or DT) to generate value for key parties (users in the totality), and to develop and gain the capacity for quickly adapting to situations which are altering.Any item or service may now be marketed but also advertised to customers online thanks to change carried out in a data - driven method, which has done away with the need for external middlemen. A large number of firms are impacted by COVID-19 since it has an impact to the entire globe and causes social estrangement with customers. In light of social distance, a wide range of sectors and businesses will be impacted. In this research, the idea of digitisation is proposed as a projected way through. Social distance may alter the characteristics or the purchasing habits. This study is being done to determine how it COVID-19 problem will affect consumer purchasing habits. By using internet tactics and strategies, consumers are shifting the way that merchandise and services are traditionally purchased. As per research, the digital advertising framework has permeated our imagination for acquiring the ways that are best for selling from several top-performing businesses.Only thing changing in regard of consumer purchase intention following COVID-19 recuperation would be the sales for items, which will mostly stay same with. Consumers will develop the buying habit so as protection, physically or straight from creators. © 2023 IEEE.

4.
Información tecnológica ; 34(2):75-88, 2023.
Article in Spanish | Academic Search Complete | ID: covidwho-2295866

ABSTRACT

This research presents the implementation of a web system to manage the food supply chains of community and family associations in the Province of Tungurahua, Ecuador. The methodology is based on the phases of the cascade development model that allows gathering information on the most relevant business needs. This includes the design and development of the software product for its subsequent validation process. The results show that the implementation of a web system configured under Odoo ERP streamlines the marketing processes and improves the traceability of the products in the study area. It is concluded that the implemented system responds to the needs of the agricultural sector, supports the creation of new channels, and improves the management of the marketing processes of post-COVID-19 food chain products. (English) [ FROM AUTHOR] Esta investigación presenta la implementación de un sistema web para gestionar las cadenas de suministros de alimentos de las asociaciones comunitarias y familiares de la Provincia de Tungurahua, Ecuador. La metodología está basada en las fases del modelo de desarrollo en cascada que permite recabar información de las necesidades de negocio más relevantes. Este incluye el diseño y desarrollo del producto de software para su posterior proceso de validación. Los resultados reflejan que la implementación de un sistema web configurado bajo Odoo ERP agilita los procesos de comercialización y mejora la trazabilidad de los productos de la zona de estudio. Se concluye que el sistema implementado responde a las necesidades del sector agrícola, apoya la creación de nuevos canales y mejora la gestión de los procesos de comercialización de productos de las cadenas alimentarias post COVID-19. (Spanish) [ FROM AUTHOR] Copyright of Información Tecnológica is the property of Centro de Informacion Tecnologica (CIT) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

5.
Cogn Behav Pract ; 2022 Feb 23.
Article in English | MEDLINE | ID: covidwho-2296442

ABSTRACT

In response to the COVID-19 pandemic and consequential shutdown measures, many mental health professionals started providing therapy to patients exclusively via telehealth. Our research center, which specializes in studying and treating obsessive-compulsive disorder (OCD), historically has provided in-person exposure and response prevention (ERP) to adults with OCD, but shifted to telehealth during the pandemic. Unlike in other modes of talk therapy, ERP's emphasis on therapist-supervised exposures presented unique opportunities and challenges to delivering treatment entirely via a virtual platform. This paper provides case examples to illustrate lessons we learned delivering ERP exclusively via telehealth in New York from March 2020 through June 2021 and offers recommendations for future study and practice. Though we observed a number of drawbacks to fully remote ERP, we also discovered advantages to delivering ERP this way, meriting additional research attention.

6.
Business Process Management Journal ; 2023.
Article in English | Scopus | ID: covidwho-2277339

ABSTRACT

Purpose: Generally, the use of cloud-based services has proliferated all around the world. This tendency increased dramatically during the coronavirus disease 2019 (COVID-19) pandemic when many people were obliged to conduct business remotely. This research study aims to investigate the intentions to adopt (IA) cloud-based enterprise resource planning (ERP) systems in Jordan, as this sort of research is scarce in developing countries. Specifically, this research study combined the model of Diffusion of Innovation (DOI) and the Technology-Organization-Environment (TOE) framework, in addition to looking at COVID-19 as a moderating variable. Design/methodology/approach: Data were collected from 60 participants working in Jordanian companies that currently use, or have the intention to use, cloud-based ERP systems. An online questionnaire was developed and used to collect responses. The study hypotheses were examined statistically using simple regression analysis and hierarchical multiple regression. Findings: The study results clearly indicate that complexity, observability, employee information technology (IT) skills, organizational culture (OC) and top management support significantly affect the intention to adopt cloud-based ERP systems. In contrast, relative advantage (RA), compatibility, trialability, regulatory environment and competitive pressure had no significant effect on adoption intention. Interestingly, the advent of COVID-19 increased the intention to adopt cloud-based ERP systems. Research limitations/implications: The study's findings will provide theoretical and practical suggestions for the effective adoption of cloud ERP in Jordan, as well as aiding other developing nations in comparable situations in implementing cloud-based ERP systems. Originality/value: The study enriches the knowledge and further examines the underlying reasons for adopting cloud-based ERP systems in a developing country. © 2023, Emerald Publishing Limited.

7.
26th International Congress on Project Management and Engineering (Terrassa), CIDIP 2022 ; 2022-July:2050-2062, 2022.
Article in Spanish | Scopus | ID: covidwho-2260963

ABSTRACT

The management and evaluation of projects is an art, teaching this art in educational projects is a challenge. Students are required to have a specific vision of the organizations to be able to define both the problem and with this, define the project that solves the problem, the visits and interaction with the organizations allow students to have the context to generate their project. Due to the confinement by Covid19, educational innovations were generated that allowed simulating the car manufacturing process, as well as the transactions carried out in the different entities of the organization through an online ERP simulator called VEP (Virtual Enterprise Planning) and the use of mixed reality lessons (virtual and augmented). In the simulation, it was possible to replicate problems that had to be solved with a project, which was designed and managed by the students. In this paper, we share the methodologies for the design of learning activities and the preparation of lessons in virtual and augmented reality, as well as the results obtained in their application in administration and project management courses. © 2022 by the authors. Licensee AEIPRO, Spain.

8.
4th International Conference on Informatics, Multimedia, Cyber and Information System, ICIMCIS 2022 ; : 509-513, 2022.
Article in English | Scopus | ID: covidwho-2283181

ABSTRACT

Initially, many companies implemented Enterprise Resource Planning (ERP) to process business transactions. However, because of COVID-19 and competitive pressure, companies expect ERP to play a higher role in increasing business process outcomes and agility. This study investigates the effects of ERP usage on business process outcomes and organizational agility in one of the largest telecommunication companies in Indonesia as the company struggles to redefine its huge ERP investment. The research deployed a purposive sampling technique involving 170 employees in one of the largest telecommunication companies in Indonesia who use an ERP system. Quantitative data was collected through online surveys using a 5-point Likert scale questionnaire. Interviews and observations were also conducted as a complement to the quantitative data. The findings of our study suggested that there are significant positive effects of ERP usage on organizational agility and business process outcomes. Furthermore, business process outcomes positively impacts organizational agility. © 2022 IEEE.

9.
The International Journal of Quality & Reliability Management ; 40(4):889-921, 2023.
Article in English | ProQuest Central | ID: covidwho-2281694

ABSTRACT

PurposeMany organizations failed to generate profits after investing considerable money and time in Enterprise Resource Planning (ERP) systems. This study, therefore, sought to identify the challenges encountered by pharmaceutical firms during the post-implementation of ERP systems.Design/methodology/approachA case-based study followed by general survey-based research was carried out in pharmaceutical firms to determine the critical post-implementation challenges of ERP systems. DANP (DEMATEL-based ANP) and Wilcoxon Signed Rank test were used to find the causal/critical challenges and rank them.FindingsAfter analyzing a pharmaceutical case company and conducting a general survey among pharmaceutical companies, statistical analysis was performed to identify the most significant challenges, namely, "Inefficient troubleshooting mechanism”, "Lack of training during post-implementation stage” and "Difficulty in identifying invalid data when entered into the ERP system”. Furthermore, organization-wide challenges are considered to be the most important.Practical implicationsThe paper identifies the challenges faced during the post-implementation phase of ERP systems. This work brings out the issues with ERP systems' performance after their implementation, which is related to the quality of the ERP systems. This work will support the risk identification and mitigation during ERP implementation to eradicate the problems after its implementation. This work may trigger the ERP system developers to improve its features and performance for better manufacturing and supply chain management system in pharmaceutical firms.Originality/valueThis study is uniquely conducted in pharmaceutical firms to study the benefits and challenges of adopted ERP systems. A pilot case study served as the foundation for the generalizability of other pharmaceutical firms' findings through a non-parametric test.

10.
Front Neurosci ; 17: 1019778, 2023.
Article in English | MEDLINE | ID: covidwho-2286868

ABSTRACT

Brain fog is a kind of mental problem, similar to chronic fatigue syndrome, and appears about 3 months after the infection with COVID-19 and lasts up to 9 months. The maximum magnitude of the third wave of COVID-19 in Poland was in April 2021. The research referred here aimed at carrying out the investigation comprising the electrophysiological analysis of the patients who suffered from COVID-19 and had symptoms of brain fog (sub-cohort A), suffered from COVID-19 and did not have symptoms of brain fog (sub-cohort B), and the control group that had no COVID-19 and no symptoms (sub-cohort C). The aim of this article was to examine whether there are differences in the brain cortical activity of these three sub-cohorts and, if possible differentiate and classify them using the machine-learning tools. he dense array electroencephalographic amplifier with 256 electrodes was used for recordings. The event-related potentials were chosen as we expected to find the differences in the patients' responses to three different mental tasks arranged in the experiments commonly known in experimental psychology: face recognition, digit span, and task switching. These potentials were plotted for all three patients' sub-cohorts and all three experiments. The cross-correlation method was used to find differences, and, in fact, such differences manifested themselves in the shape of event-related potentials on the cognitive electrodes. The discussion of such differences will be presented; however, an explanation of such differences would require the recruitment of a much larger cohort. In the classification problem, the avalanche analysis for feature extractions from the resting state signal and linear discriminant analysis for classification were used. The differences between sub-cohorts in such signals were expected to be found. Machine-learning tools were used, as finding the differences with eyes seemed impossible. Indeed, the A&B vs. C, B&C vs. A, A vs. B, A vs. C, and B vs. C classification tasks were performed, and the efficiency of around 60-70% was achieved. In future, probably there will be pandemics again due to the imbalance in the natural environment, resulting in the decreasing number of species, temperature increase, and climate change-generated migrations. The research can help to predict brain fog after the COVID-19 recovery and prepare the patients for better convalescence. Shortening the time of brain fog recovery will be beneficial not only for the patients but also for social conditions.

11.
J Biol Chem ; 299(2): 102836, 2023 02.
Article in English | MEDLINE | ID: covidwho-2239311

ABSTRACT

Gap junctional intercellular communication (GJIC) involving astrocytes is important for proper CNS homeostasis. As determined in our previous studies, trafficking of the predominant astrocyte GJ protein, Connexin43 (Cx43), is disrupted in response to infection with a neurotropic murine ß-coronavirus (MHV-A59). However, how host factors are involved in Cx43 trafficking and the infection response is not clear. Here, we show that Cx43 retention due to MHV-A59 infection was associated with increased ER stress and reduced expression of chaperone protein ERp29. Treatment of MHV-A59-infected astrocytes with the chemical chaperone 4-sodium phenylbutyrate increased ERp29 expression, rescued Cx43 transport to the cell surface, increased GJIC, and reduced ER stress. We obtained similar results using an astrocytoma cell line (delayed brain tumor) upon MHV-A59 infection. Critically, delayed brain tumor cells transfected to express exogenous ERp29 were less susceptible to MHV-A59 infection and showed increased Cx43-mediated GJIC. Treatment with Cx43 mimetic peptides inhibited GJIC and increased viral susceptibility, demonstrating a role for intercellular communication in reducing MHV-A59 infectivity. Taken together, these results support a therapeutically targetable ERp29-dependent mechanism where ß-coronavirus infectivity is modulated by reducing ER stress and rescuing Cx43 trafficking and function.


Subject(s)
Disease Susceptibility , Endoplasmic Reticulum , Host Microbial Interactions , Molecular Chaperones , Murine hepatitis virus , Animals , Mice , Astrocytoma/pathology , Astrocytoma/virology , Brain Neoplasms/pathology , Brain Neoplasms/virology , Cell Communication , Cell Line, Tumor , Connexin 43/metabolism , Endoplasmic Reticulum/metabolism , Endoplasmic Reticulum Stress , Gap Junctions/metabolism , Heat-Shock Proteins/genetics , Heat-Shock Proteins/metabolism , Molecular Chaperones/genetics , Molecular Chaperones/metabolism , Murine hepatitis virus/metabolism , Protein Transport , Transfection
12.
Syst Pract Action Res ; : 1-30, 2022 May 31.
Article in English | MEDLINE | ID: covidwho-2227317

ABSTRACT

The purpose of this paper was to examine the cultural barriers that existed at various stages of the Enterprise Resource Planning (ERP) implementation process, using the Middle-Eastern oil and gas sector as a case study. Due to a variety of cultural implications, ERP implementation rates in the oil and gas sector in Middle-Eastern developing countries are extremely low. Although the literature highlighted numerous ERP implementation theories that attempted to overcome the cultural complexities of ERP systems, there are few studies that have framed these complexities using action research theory in order to provide potential solutions to these challenges, particularly in Middle-Eastern developing countries where cultural settings are distinct from those in Western developed countries. Action research AR, in conjunction with documentation, observations, and interviews, aided in the exploration of the culturally complex barriers encountered during the pre-implementation (plan and propose), implementation (do), and post-implementation (assess and improve) stages of ERP projects conducted within a Middle-Eastern oil and gas organisation. This article confirms numerous cultural implications at each stage of the ERP implementation process, including team conflict, managerial authority, and a lack of an IT culture, all of which contributed to the project's delay. Other impediments, such as a lack of commitment to training and technophobia, persisted throughout the post-implementation phase and the subsequent follow-up experience under the recent COVID-19 pandemic. This article contributes to theory and practise by highlighting the culturally complex barriers that underpin many ERP implementations in the Middle Eastern oil and gas sector. This information can assist practitioners and researchers in developing future research and ideas to mitigate future ERP implementation challenges in this region.

13.
2nd International Conference on Information Technology, Advanced Mechanical and Electrical Engineering, ICITAMEE 2021 ; 2499, 2022.
Article in English | Scopus | ID: covidwho-2186574

ABSTRACT

The Covid-19 pandemic has shattered the stability of small businesses and forced industrial activity to be digitally computed. In the form of prevention due to the clusterization of covid-19, physical contact must be avoided in any form. In the case of industry, cloud-based and online operations are intensively developed by companies and SMEs to stop the transmission chain of the COVID-19 pandemic. One form of development of automation technology in an industry is the implementation of an ERP system. As the main role in a company to receive revenue from direct customers, the sales module must be flexible, so that it can be used in various types of terms, times, and conditions. Sales, which are the frontline of calculating profits and the front-end to customers, also play a large role in determining profit based on gross revenue from customers who come and buy the company's products and services. As a reference for the success of ERP implementation, the quickstart methodology is used to measure the effectiveness of the system from the design made. This study aims to form an ERP-based smart system design for sales operation and electronic invoice management modules to synergise IT developments and industrial needs during the Covid-19 pandemic. © 2022 American Institute of Physics Inc.. All rights reserved.

14.
22nd Annual General Assembly of the International Association of Maritime Universities Conference, AGA IAMUC 2022 ; 2022-October, 2022.
Article in English | Scopus | ID: covidwho-2169937

ABSTRACT

The article discusses and analyses the importance of the Enterprise Resource Planning (ERP) principles in the University environment. It is crucial to properly evaluate and assess the effectiveness of the university's administrative and academic staff performances as an organizational form. In the last couple of years, besides the negative impact, COVID-19 positively impacted the technological development at the HEIs. So, the ERP system remains a powerful program that allows businesses to systematize all important processes. Drastically, doing so reduces costs and the possibility of making mistakes, thereby increasing efficiency and profitability. The ERP system comprises the main sections of an organization, such as financial, human resources, production, logistics, etc., but to the present does not cover the whole university's administrative and learning activities. Thus, most HEIs effectively implement technologies and E-Systems but, in most cases, are fragmented and do not cover whole university activities. The purpose of the article is to create one united platform based on an ERP system, whereby we will get the new model of the University Recourse Planning (URP) system and will be implemented and facilitate the: unified digital database, improvement of university efficiency, less bureaucracy, delayed decisions and the and quality improvement. As a result, all the data will be shown as a "Dashboard" to the top management of HEI, which will perceive information about the weaknesses and gaps for achieving specific objectives. © 2022 IAMUC. All Rights Reserved.

15.
2022 Central and Eastern European eDem and eGov Days: Hate Speech and Fake News - Fate or Issue to Tackle?, CEEeGov 2022 ; : 130-134, 2022.
Article in English | Scopus | ID: covidwho-2162019

ABSTRACT

COVID-19 accelerated the drive towards distance learning, typically supported by web-based eLearning resources. There are also studies reviewing the transition to such as teaching style, whether in conjunction with traditional classroom teaching or as a supplement. This paper will focus on ERP-based teaching within a larger program to establish tertiary distance education in eGovernment in Germany ("eGov Campus"). It attempts to structure the topic and to advance some hypotheses that will be empirically tested against real-world data and experience from introducing this style of teaching in the eGov Campus. © 2022 ACM.

16.
8th International Conference on Technologies and Innovation, CITI 2022 ; 1658 CCIS:75-89, 2022.
Article in English | Scopus | ID: covidwho-2148614

ABSTRACT

The digital transformation of healthcare companies in times of Covid-19 was a relevant factor in sustaining the great demand for healthcare services, allowing the establishment of new communication channels, forms of payment, information processing, and online medical consultation services, among other services. This transformation implies substantial changes in people’s culture and businesses, through a systematic, strategic and cultural change process, supported by the application of cutting-edge technologies that allow the systematization of processes and adequate data analysis. This research shows the digital transformation of the Médikal Center, which integrated technological changes within its processes such as migration to a cloud computing scheme allowing optimization of investment costs in IT infrastructure;migration to a more stable ERP;replacement of manual clinical laboratory processes by automated processes;generation of dynamic reports using data analytics thus improving decision-making at the managerial level;and establishment of new contact channels with the user such as the chatbot and mobile applications that allowed greater attention to customer demand. In short, this digital transformation process has allowed improving the quality of service, customer satisfaction, and supporting the decision-making of the company’s executives, but in order to achieve this purpose, it was necessary to use methodologies supported by the best practices in the management of planning and implementation of IT projects. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

17.
Cognitive Behaviour Therapist ; 15:21, 2022.
Article in English | Web of Science | ID: covidwho-1977952

ABSTRACT

The lifetime prevalence of OCD in the UK is estimated to be between 1 in 100 and 1 in every 50 people. It is therefore necessary to explore innovations in practice to expand the reach of the gold standard therapeutic approaches of exposure with response prevention (ERP) and cognitive behavioural therapy (CBT). The COVID-19 pandemic has facilitated such innovations with several services accommodating changes to routine practice by utilising digital platforms to provide videoconference-delivered therapy. Despite a growing evidence base demonstrating efficacy and scope for the use of videoconference-delivered CBT for obsessive-compulsive disorder (OCD), there remains qualitative research collated from clinicians which suggests that a lack of practitioner confidence and a low belief in positive outcomes are barriers to adopting remote therapy practices for clinicians. Therefore, this structured case report describes the assessment, formulation, intervention and outcome of an 11-week videoconference-delivered therapeutic intervention. Reflections are made regarding the use of the digital platform throughout the intervention, alongside the strengths and difficulties of applying videoconference-delivered CBT for OCD.

18.
Front Hum Neurosci ; 16: 884251, 2022.
Article in English | MEDLINE | ID: covidwho-1924133

ABSTRACT

More than 200 million children under the age of 5 years are affected by malnutrition worldwide according to the World Health Organization. The Barbados Nutrition Study (BNS) is a 55-year longitudinal study on a Barbadian cohort with histories of moderate to severe protein-energy malnutrition (PEM) limited to the first year of life and a healthy comparison group. Using quantitative electroencephalography (EEG), differences in brain function during childhood (lower alpha1 activity and higher theta, alpha2 and beta activity) have previously been highlighted between participants who suffered from early PEM and controls. In order to determine whether similar differences persisted into adulthood, our current study used recordings obtained during a Go-No-Go task in a subsample of the original BNS cohort [population size (N) = 53] at ages 45-51 years. We found that previously malnourished adults [sample size (n) = 24] had a higher rate of omission errors on the task relative to controls (n = 29). Evoked-Related Potentials (ERP) were significantly different in participants with histories of early PEM, who presented with lower N2 amplitudes. These findings are typically associated with impaired conflict monitoring and/or attention deficits and may therefore be linked to the attentional and executive function deficits that have been previously reported in this cohort in childhood and again in middle adulthood.

19.
Polymers (Basel) ; 14(13)2022 Jun 25.
Article in English | MEDLINE | ID: covidwho-1911512

ABSTRACT

Nowadays, tuberculosis is the second leading cause of death from a monopathogenic transmitted disease, only ahead of COVID-19. The role of exported repetitive protein (Erp) in the virulence of Mycobacterium tuberculosis has been extensively demonstrated. In vitro and in vivo assays have identified that Erp interacts with Rv1417 and Rv2617c proteins, forming putative transient molecular complexes prior to localization to the cell envelope. Although new insights into the interactions and functions of Erp have emerged over the years, knowledge about its structure and protein-protein interactions at the atomistic level has not been sufficiently explored. In this work, we have combined several in silico methodologies to gain new insights into the structural relationship between these proteins. Two system conditions were evaluated by MD simulations: Rv1417 and Rv2617c embedded in a lipid membrane and another with a semi-polar solvent to mimic the electrostatic conditions on the membrane surface. The Erp protein was simulated as an unanchored structure. Stabilized structures were docked, and complexes were evaluated to recognize the main residues involved in protein-protein interactions. Our results show the influence of the medium on the structural conformation of proteins. Globular conformations were favored under high polarity conditions and showed a higher energetic affinity in complex formation. Meanwhile, disordered conformations were favored under semi-polar conditions and an increase in the number of contacts between residues was observed. In addition, the electrostatic potential analysis showed remarkable changes in protein interactions due to the polarity of the medium, demonstrating the relevance of Erp protein in heterodimer formation. On the other hand, contact analysis showed that several C-terminal residues of Erp were involved in the protein interactions, which seems to contradict experimental observations; however, these complexes could be transient forms. The findings presented in this work are intended to open new perspectives in the studies of Erp protein molecular interactions and to improve the knowledge about its function and role in the virulence of Mycobacterium tuberculosis.

20.
Journal for Educators Teachers and Trainers ; 13(2):1-12, 2022.
Article in English | Web of Science | ID: covidwho-1897373

ABSTRACT

Transforming the educational model for higher education in the context of digital transformation is an inevitable trend. This represents the right direction to take advantage of the 4.0 technology revolution, creating high-quality human resources to meet the requirements of the labor market. The purpose of the study is to analyze the appropriate higher education model in the context of the digital economy towards the development of high-quality human resources to participate in the operation of the digital economy. The requirements for the development of digital universities for countries in general and Vietnam in particular need to constantly innovate and reform the national education systems to further improve the quality and effectiveness of higher education, towards an education that adapts to the context of digital transformation and the covid 19 epidemic. The issue of the quality of human resources must be concerned by education systems to make breakthrough changes and should be prioritized by countries. The article uses qualitative, quantitative, comparative, survey survey and experimental data analysis methods. The survey was conducted on 100 businesses that have cooperation activities with the university through online form via email. The main results of the study provide solutions for adjusting the training methods and models at universities in Vietnam in response to the 4.0 technology revolution and the covid 19 epidemic.

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